EFFECT OF PRE-DIALYSIS PLASMA SODIUM ON WEIGHT GAIN AND CLINICAL SYMPTOMS IN PATIENTS ON MAINTENANCE HEMODIALYSIS
Abstract
Background: Extracellular fluid volume overload is mainly determined by changes in sodium concentration and can be assessed through interdialytic weight gain, symptoms of fluid overload, and intradialytic clinical signs. It is therefore important to establish if sodium concentration can explain weight gain as well as clinical symptoms in these patients.
Objective: The goal of this study describe the relationship between pre-dialysis plasma sodium levels and weight gain in individuals on maintenance HD, as well as intradialytic and interdialytic symptoms.
Methods: This study was a prospective observational study involving CKD patients undergoing twice-weekly HD at the nephrology unit of Douala General Hospital. The study was conducted over 2 months and each patient included was met twice. Three blood samples were collected from each patient that is, the first and second samples before and at the end of the dialysis and the last sample the before the beginning of the next dialysis session. All blood samples were analyzed in the hospital laboratory for sodium concentration. Using data extraction from clinical, physical parameters as well as symptoms were recorded. The data were analyzed using the statistical package for social sciences (SPSS) version 27.
Results: We included 133 patients. The mean age was 45.37+/-12.68 years and 68.4% were males. The mean duration for dialysis was 3 years. About 63% (84) of patients had pre-dialysis hyponatremia and 70% a normal sodium concentration after dialysis. No case of hypernatremia was observed. The most common symptoms experienced during and in between dialysis sessions in order of prevalence were fatigue (53.3%), cramps (38.2%), and thirst (36.1%). About 75% had low sodium (<135mmol/L) before dialysis, Low pre- dialysis sodium concentration had a linear relationship with high interdialytic weight gain (IDWG) and pre-dialysis SBP. But most of the clinical symptoms experienced were significantly associated with UF volume rather than pre-dialysis sodium. There was no relationship between post-dialysis sodium and IDWG.
Conclusion: Hyponatremia is the most common observed sodium abnormality and can predict IDWG and pre-dialysis SBP.
Check out: Health Science Project Topics with Materials
| Project Details | |
| Department | Health Science |
| Project ID | HS0067 |
| Price | Cameroonian: 5000 Frs |
| International: $15 | |
| No of pages | 55 |
| Methodology | Descriptive |
| Reference | yes |
| Format | MS word & PDF |
| Chapters | 1-5 |
| Extra Content | table of content, questionnaire |
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EFFECT OF PRE-DIALYSIS PLASMA SODIUM ON WEIGHT GAIN AND CLINICAL SYMPTOMS IN PATIENTS ON MAINTENANCE HEMODIALYSIS
| Project Details | |
| Department | Health Science |
| Project ID | HS0067 |
| Price | Cameroonian: 5000 Frs |
| International: $15 | |
| No of pages | 55 |
| Methodology | Descriptive |
| Reference | yes |
| Format | MS word & PDF |
| Chapters | 1-5 |
| Extra Content | table of content, questionnaire |
Abstract
Background: Extracellular fluid volume overload is mainly determined by changes in sodium concentration and can be assessed through interdialytic weight gain, symptoms of fluid overload, and intradialytic clinical signs. It is therefore important to establish if sodium concentration can explain weight gain as well as clinical symptoms in these patients.
Objective: The goal of this study describe the relationship between pre-dialysis plasma sodium levels and weight gain in individuals on maintenance HD, as well as intradialytic and interdialytic symptoms.
Methods: This study was a prospective observational study involving CKD patients undergoing twice-weekly HD at the nephrology unit of Douala General Hospital. The study was conducted over 2 months and each patient included was met twice. Three blood samples were collected from each patient that is, the first and second samples before and at the end of the dialysis and the last sample the before the beginning of the next dialysis session. All blood samples were analyzed in the hospital laboratory for sodium concentration. Using data extraction from clinical, physical parameters as well as symptoms were recorded. The data were analyzed using the statistical package for social sciences (SPSS) version 27.
Results: We included 133 patients. The mean age was 45.37+/-12.68 years and 68.4% were males. The mean duration for dialysis was 3 years. About 63% (84) of patients had pre-dialysis hyponatremia and 70% a normal sodium concentration after dialysis. No case of hypernatremia was observed. The most common symptoms experienced during and in between dialysis sessions in order of prevalence were fatigue (53.3%), cramps (38.2%), and thirst (36.1%). About 75% had low sodium (<135mmol/L) before dialysis, Low pre- dialysis sodium concentration had a linear relationship with high interdialytic weight gain (IDWG) and pre-dialysis SBP. But most of the clinical symptoms experienced were significantly associated with UF volume rather than pre-dialysis sodium. There was no relationship between post-dialysis sodium and IDWG.
Conclusion: Hyponatremia is the most common observed sodium abnormality and can predict IDWG and pre-dialysis SBP.
Check out: Health Science Project Topics with Materials
This is a premium project material, to get the complete research project make payment of 5,000FRS (for Cameroonian base clients) and $15 for international base clients. See details on payment page
NB: It’s advisable to contact us before making any form of payment
Our Fair use policy
Using our service is LEGAL and IS NOT prohibited by any university/college policies. For more details click here
We’ve been providing support to students, helping them make the most out of their academics, since 2014. The custom academic work that we provide is a powerful tool that will facilitate and boost your coursework, grades and examination results. Professionalism is at the core of our dealings with clients
For more project materials and info!
Contact us here
OR
Click on the WhatsApp Button at the bottom left
Email: info@project-house.net
