Abstract

There have being an in increase prevalence of microbial infectious disease and their complication mainly due to microbial drug resistance toward commonly used antimicrobials. Thus the need for new antimicrobials sources like plants is imperative. This study aimed at determining the types of plants used against diseases caused by multidrug resistant bacteria and evaluating the antimicrobial activity of five of those plants.

A cross sectional and experimental study design was employed using questionnaires to collect ethnobotanical data  and MIC and MBC, phytochemical screening was done on five selected plants following CLSI standards and results analyzed using  GraphPad prism. Results: 36 traditional practitioners interviewed during this study, 29 were men and 7 women.

Manyu division had the highest numbers of traditional practitioners who participated in this survey, a total of 57 plants belonging to 33 families were identified and with a frequency of 13/57, astereae was the most represented family followed by that of fabaceae (04/57) and amarathaceae (03/57).

The most plant parts used were leaves (59.6%). decoction and maceration were the most used (36.8%). E. divaricata and P.  Africanum gave significant zones of inhibitions (16 -17mm) with extracts being active against at least three test strains with MIC of 60 ug/ml, the types of phytochemicals present in the different medicinal plants with P. Africanum, and E. divaricata having alkaloids, flavoid, and terpenoids.

Wide varieties of plants are used for medicinal purposes and most of traditional practitioners possess traditional knowledge on anti-infectious plants that are efficient and cost-effective for the treatment of diseases caused by multidrug resistant bacteria. E. divaricata, P. Angolensis and P. Africanum exhibited beneficial antibacterial activity against S. aureus, P. aeroginosa, K. pneumonia, and E. coli.

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